1991 Volume 6 Issue 5 Pages 817-822
The absorption and excretion of DR-3355, a new quinolone antimicrobial agent, were investigated in male dogs after a single oral administration at a dose of 20mg/kg.
1. Blood levels of radioactivity reached a peak at 4hr and Cmax was 6.38 μg equiv. to DR-3355/ml. After reaching the Cmax, the blood and serum levels were decreased gradually with t1/2s 8.4 and 8.7hr, respectively. At 72hr after administration, the radioactivity in the blood was not detected.
2. Blood cell binding and serum protein binding were almost constant with time, accounting for 42 ?? 48 and 26 ?? 39%, respectively.
3. Most of radioactivity was recovered into urine and feces within 48hr after administration. Cumulative excretions of radioactivity in urine and feces at 120hr were 54.4 and 39.4%, respectively.
