Brain distribution of HY-770 in rat —Computer-assisted image analysis of local distribution in brain—

Abstract

Distribution of radioactivity into the brain and spinal cord was studied after oral administration of ¹⁴C-HY-770 in rats. The radioactivity was measured by the quantitative analysis of autoradiogram. The autoradiogram was recorded by video camera system and then analyzed with computer-assisted image analyzer.
1. The distribution of radioactivity in each region of the brain was uniform at any measurment points.
2. The concentration in the spinal gray matter was nearly equal to the regions in the brain, but the concentration in the spinal white matter was slightly lower than that in other regions.
3. The all regions in the brain and spinal cord showed higher concentration than in the blood. The differences of the partition ratios (each region/ blood) depending on a measurement time were not observed.