1992 Volume 7 Issue 6 Pages 787-797
After oral administration of (pivaloyloxymethyl-14C) ME1207 to rats, the radioactivity derived from the oxymethylene moiety in the ester group was well absorbed and the absorption extent was more than 90% of administered dose.
The radioactivity was mainly excreted with expired air as the 14CO2. The cumulative excretion with expired air within 168hr accounted to 67.9% of the dosed radioactivity.
The tissue levels of the radioactivity were high and prolonged in most tissues, especially in the bone marrow, intestinal mucosa, pancreas and Harderian gland.