Pharmacokinetic studies of terguride (2): Absorption and excretion in rabbits

Abstract

The absorption and excretion of terguride in rabbits were studied.
1. After oral administration of ¹⁴C-terguride (1 mg/kg) to female rabbits, the radioactivity in plasma reached the maximum (C_max) at 1hr and disap peared with a half-life of 1.9hr. Concentration of terguride in plasma reached C_max at 0.25 ?? 1 hr and disappeared with a half-life of 1.2hr. Similar plasma kinetics was observed in male rabbits. Urinary and fecal excretion within 7days after oral dosing was 41 and 53%, respectively.
2. The bioavailability of terguride after oral administration was about 39%
3. Food intake before oral administration of unlabelled terguride (0.2mg/animal) decreased (about 30%) the C_max, whereas the increase was induced by neutralization of stomach pH, however, no effect of their treatment on T_max and availability was found.