Cystic Bile Duct Adenoma with Cholangiocellular Carcinoma in a Cat

Abstract

An 11-year-old castrated Persian cat with abdominal distention and hyposthenea, and which had been anorexic for a few days, was brought to our hospital. The cat had received supportive therapy for two years for chronic renal failure and feline immunodeficiency virus (FIV) intection. Abdominal radiography and ultrasonography revealed a large cyst with a liquid pool in the rear hepatic margin. Apart form abnormal values related to chronic renal failure, the findings of hemogram and blood chemistry analysis were normal. When an abdominal median section was performed, a large dark-red cyst stemming from the left inner lobe of the liver was found. The cyst was filled with a large amount of liquid, with small masses scattered on the membrane surface of the cyst. This lobe was resected with the cyst. Histopathologically, the disease was dignosed as a cystic bile duct adenoma with cholangiocellular carcinoma. The cat was euthanized 23 months after lobectomy, since its chronic renal failure worsened, although liver function values were normal. Pathological examination showed the presence of a number of cystic bile duct adenomas in the liver, but no recurrence of the cholangiocellular carcinoma.