Hypoadrenocortism after Long-term Therapy with Chlormadinone Acetate in a Dog

Abstract

A four-years-old, male miniature dachshund was brought to us with perianal lesions. The dog was found suffering from hepatopathy, which was considered side effect of long-term medication with chlormadinone acetate. The dog had had a history of prostatomegaly, and been treated with chlormadinone acetate, a progesterone preparation, for two years at another hospital. We stopped giving the medicine since there were no signs of prostatomegaly. But on day 27, the dog showed severe abdominal pain and vomiting. An ACTH stimulation test revealed that this time the dog was suffering iatrogenic secondary hypoadrenocortism. Low dosage of predonisolone was effective in improving the clinical symptoms, and 206 days later predonisolone was stopped. The dog has been in good health since.