2022 Volume 31 Issue 2 Pages 57-61
A 13-year-old male beagle was brought to our hospital with a complaint of thrombocytopenia and lymphocytosis. CBC at presentation revealed mild non-regenerative anemia (Ht 28.7 %, Ret 1 %), thrombocytopenia (117×103 /μl), and severe lymphocytosis (503,148 /μl). Abdominal ultrasonography showed splenomegaly; thus, splenectomy and bone marrow examination were performed. Based on the histopathological examination of the spleen and bone marrow findings, we diagnosed lymphoma of the spleen. After surgery, lomustine and L-asparaginase were administered, and the lymphocyte count decreased to within the reference level. The results of immunostaining of the spleen and flow cytometry of the peripheral blood suggested that the tumor was derived from cytotoxic T-cells, and we finally diagnosed hepatosplenic T-cell lymphoma. Following splenectomy and chemotherapy, the clinical signs disappeared, however the response to treatment gradually worsened and the subject died on day 274.
