Efficacy of Tetrastarch Infusion on Hypotension During Hepatic Mass Resection in Dogs

Abstract

This study investigated the prevalence of hypotension during hepatic mass resection and the clinical efficacy of tetrastarch solution (TS) for intraoperative hypotension in dogs. Patients from the Veterinary Teaching Hospital of our university were enrolled. Twenty-five client-owned dogs scheduled for hepatic mass resection were included based on complete anesthetic records. Intraoperative hypotension occurred in all dogs, which were first treated with dopamine. In 16 dogs, hypotension continued even after dopamine administration, and TS was administered. The hypotension improved after TS administration in 11 dogs (69%). However, five (31%) dogs did not recover from the hypotension after TS administration and needed extra vasoconstrictors such as ephedrine or norepinephrine. Our data demonstrate that the infusion of TS may serve as an option to treat persistent intraoperative hypotension after dopamine administration in dogs if the loss of intravascular volume is moderated during hepatic mass resection.