Male mediated developmental toxicity

Abstract

Less than 10% of drug-candidate compounds are associated with testicular toxicity. Therefore, developmental toxicity, such as paternally transmitted birth defects, is concerned if genetic abnormalities in the germ line persist and accumulate in the sperm during the spermatogenesis cycle. This paper will provide an overview of chemical and testicular toxicity and a forum for considering developmental toxicity from the perspective of male reproduction, which is often overlooked in the Developmental Origins of Health and Disease (DOHaD) discourse.