2013 Volume 71 Issue 3 Pages 130-137
Objective: In this study, the effect of fermented brown rice (FBR) on glycemic control was examined in Zucker diabetic fatty (ZDF) rats, which served as type 2 diabetes mellitus models.
Methods: ZDF rats were divided into the normal meals group (DMC) and the FBR intake group (DMF). The non-diabetic control group (NDM) included regular lean Zucker rats. The DMC and NDM rats were provided with normal meals containing 2.5% of powdery normal brown rice, while the DMF rats were provided with feed containing 2.5% of FBR. The rats underwent an oral glucose tolerance test after administration of 2 g/kg body weight of glucose after 3 weeks of breeding.
Results: The homeostasis model assessment ratio indicated higher insulin resistance, in DMF and DMC groups than in NDM. With regard to the change in blood sugar levels, the peak level in DMC was 60 min after glucose administration (427.4±20.2 mg/dl, Mean±standard error of the mean), while that in DMF and NDM were 30 min after glucose administration (DMF, 318.7±16.2 mg/dl; NDM, 166.1±5.1 mg/dl). In addition, the decline in the blood sugar level was faster in DMF than DMC, with significantly low values at 60, 90, and 120 min after glucose administration. The total area under the blood concentration-time curve of blood sugar level and insulin level was significantly more in DMF than in NDM, but was significantly lower than that in DMC.
Conclusions: These results suggest that diet intake supplemented with FBR could improve glucose tolerance in type 2 diabetes mellitus rat models.
