Abstract
The interaction of hypocholesterolemic food components on cholesterol metabolism in rats was studied.
One of hypocholesterolemic food components was crude konjac mannan prepared from the tubers of Amorphophallus konjac K. Koch (Araceae), and another was eritadenine which was isolated from a species of mushrooms, SHIITAKE or Lentinus edodes. Sprague-Dawley strain male rats were fed on a hypercholesterolemic diet containing 1% cholesterol and 0.25% bile salts. Test substances were supplemented to the hypercholesterolemic diet with crude konjac mannan 0-10% levels and/or eritadenine 0-0.005% levels.
Results obtained were as follows;
1) The hypocholesterolemic effects of crude konjac mannan on serum and liver were reconfirmed.
2) Eritadenine lowered serum cholesterol level but did not show any effect on liver cholesterol level.
3) Concomitant administration of crude konjac mannan and eritadenine affected additively on serum cholesterol level. However, liver cholesterol level was decreased only by the activity of crude konjac mannan.
