Abstract
The effect of short-term feeding of various chlorophyll derivatives and its constituents was examined in rats maintained on diets containing 1% cholesterol and 0.25% bile salts. Cholesterol levels were determined in the serum and liver after 4 or 10 days feeding of each test substances at the 2% level.
As for the results, the cholesterol content in the serum and liver was greatly reduced in rats given Na-Cu-chlorophyllin, K-Mg-chlorophyllin and Na-phytochlorin without delay of growth. In Na-Fe-chlorophyllin, cholesterol depressing effect was observed only in the liver, not in the serum. Inhibition of growth was also found to be specific to Na-Fe-chlorophyllin fed animals. Pyrrole showed no hypocholesterolemic activity.
