2021 Volume 3 Issue 1 Pages 20-27
Purpose: The current status of polypharmacy and the effects of medications on albumin (Alb) level were examined based on previous studies that conducted subjective global assessment and anthropometry.
Subjects and Methods: Among patients whose existing medications were confirmed on hospital admission between September 3, 2018 and August 30, 2019, the percentage of those taking six or more prescribed medications was calculated. Patient characteristics and total number of medications prescribed were examined, and the relationship between 12 major medications that can cause appetite loss and change Alb level was investigated.
Results: Among 3,749 patients, 1,532 (40.9%) were taking 6 or more medications. Total number of medications did not correlate with Alb level (r =-0.083, p=0.001). The odds ratios for Alb < 3.5 g/dL were 1.421 in patients aged ≥ 75 years, 3.664 in those with moderate or severe malnutrition, 0.656 in those on NSAIDs, 2.381 in those on steroids, 0.454 in those on anticancer drugs, 2.398 in those on iron agents, and 2.178 in those on opioids.
Conclusion: The total number of medications was not significantly correlated with Alb level, but age ≥ 75 years, moderate or severe malnutrition, and use of steroids, iron agents, or opioids were factors associated with a low albumin level.
