Synthesis of atropisomeric chiral dopants applying chiral circular structure and their helical twisting power values

Abstract

New atropisomeric chiral dopants were synthesized from an optically active trans-1,2-cyclohexanedicarboxylic acid derivatives and achiral biphenols. It was found that the control of the axial chirality was useful for increasing the helical twisting power (HTP) values. On the other hand, the HTP values of the chiral dopants were strongly depended on the terminal substituents. The chiral dopant having a fluoro terminal substituent showed the largest HTP value.