Environmental Monitoring and Contaminants Research
Online ISSN : 2435-7685
Articles
Genotoxic profile among e-cigarette consumers, cigarette smokers, and nonsmokers
Ghofran AL-QUDAIHITahreer AL-RAJOUDIYara ALJERAYEDAbdulrahman BIN MUMMERMohamed SHOUKRIIman AL-SALEH
Author information
JOURNAL OPEN ACCESS FULL-TEXT HTML

2023 Volume 3 Pages 1-8

Details
Abstract

It is widely believed that e-cigarettes are less harmful than conventional cigarettes because they have a lower nicotine content. In contrast to this notion, several in vitro studies have evaluated and demonstrated the genotoxicity associated with e-cigarette smoking. However, there is a lack of human studies on the genotoxicity of e-cigarettes. This pilot study evaluated and compared indicators of genotoxicity in e-cigarette users, cigarette smokers, and nonsmokers. A total of 84 healthy participants, including 20 e-cigarette users, 31 cigarette smokers, and 33 nonsmokers, were recruited. Genotoxicity was evaluated by measuring tail moment (TM), tail length (TL), and % tail DNA intensity (%T) using the comet assay as an indicator of DNA damage in blood and detecting micronuclei in buccal cells with the buccal micronucleus (MN) cytome assay. Bivariate analyses showed that there was no significant difference in TM and TL between e-cigarette users and cigarette smokers, but in both groups, the three parameters were significantly higher than that in nonsmokers (p<0.02). In contrast, the frequency of micronuclei in e-cigarette users (40%) was higher than that in cigarette smokers (27.5%). Our findings indicate that e-cigarettes have a similar genotoxic effect to regular cigarettes and, therefore, contradict the notion that e-cigarettes are safer than regular cigarettes.

DNA damage in the blood of nonsmokers (TM=1.96), cigarette smokers (TM=16.3), and e-cigarette users (TM=10) Fullsize Image
Content from these authors
© 2023 The Authors.

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
https://creativecommons.org/licenses/by-nc-nd/4.0/
feedback
Top