Abstract
In previous experiment the author obtained the results that the blood sedimentation increases both in hyperthyroidism and in hypo- or athyroidism. He now proceeds to ascertain the pathogenesis of these change of blood sedimentation and the results are as follows : -
By Substituting the blood plasma and the blood corpuscles each other in two kinds of the blood which show different sedimentation, the author found that the cause of increase lies both in blood plasma and in blood corpuscles.
He then estimated the blood plasma proteids, i, e., fibrinogen, globulin and albumin in the animals thyroidectomized or fed on thyroid. 13 rabbits thyroidectomized show an increase in globulin in all cases, but no definite result in amount of fibrinogen and albumin. 9 cases of rabbits fed on thyroid gland show a decrease in albumin and the uncertainty in fibrinogen and globulin. The proportion of globulin to albumin increase both by thyroid feeding and by thyroidectomy.
While the thyroidectomy produces an increase in the viscosity of blood serum in all cases of 7 rabbits, thyroid feeding show a decrease in 7 cases and an increase in 4 cases, which accompanied diarrhoea.The results are not certain in 11 cases of hyperthyroidism.
The results of the estimation of the specific gravity of blood serum in 12 rabbits are uncertain. As for the relation between the thyroid gland and erythrocyt, both the haemoglobin and the number of erythrocyt decrease in all cases of thyroidectomy and increase in all cases of feeding.
The negative electric;ty of erythrocyt increases for several days after thyroidectomy, but decreases again after the days. The thyroid feeding show a decrease in it, which is remarkable in the proportion to the symptoms of thyrotoxicosis.
From these results we can maintain that the increase of blood sedimentation both in the hyperthyroidism and in the athyroidism must be due to the increase of the proportion of globulin to albumin. The decrease of erythrocyt and haemoglobin and negative electricity produced by thyroidectomy have a supplementary action upon the increase of the blood sedimentation. The decrease of viscosity and negative electricity produced by thyroid feeding also seems to act upon it supplementarily.
