Abstract
By means of Ogawa's Ferricyanide method and the representation in which the reducing power of several substance (Uric acid, Creatinine and Glucuronic acid) is expressed in the term of glucose equivalent, I studied the change of the pattern of urinary reducing substance after environmental changes or other stress.
1) In all cases of surgical operations investigated the remarkable increase of the urinary concentrations glucose or the ratio of the reducing power of glucose to that of all the reducing substances in urine (G/TR) was the most definite and constant finding. For the clinical purposes. the ratio may be a preferable indicator to the absolute value of urinary glucose.
2) In the cases under the other stressors, such as muscular excercise and low pressure environment, the similar changes of the pattern were also observed.
3) Finally, the change of the pattern of urinary reducing substances after ACTH administration was investigated and it was revealed that it caused a definite increase in the value of the G/TR after 12 hours after the administration of ACTH.
It is suggested from the results obtained that endocrine including the function of the adrenal-pituitary-system may play a important role in regulationg the change in the carbohydrate metabolism under stress, although the other various factors (viz. functions of hypothalamus, liver etc.) may be related to the metabolism.
To sum up: 1) the increase in the amount of urinary glucose and ratio of glucose to total reducing substance expressed in the term of glucose equivalent was remarkable after various stresses and the ACTH administration. 2) This led me to regard our method above described as a unique, clinical indicator of carbohydrate metabolism under stress.
