Abstract
From the views of hypothalamic-hypohyseal-gonadal system, experimental evidence pertinent to the problem of the functional relationship of the system was performed.
Results obtained were as follows:
(1) Secretion of androgenic hormones increased usually on tne third or forth day after the surgical operations. Urinary excretion of 17-ketosteroids reincreased on this period. Gonadal fractions of 17-ketosteroids showed the marked increase and excretion of hypophyseal gonadotrophin did so in parallel with increase of gonadal fractions.
(2) Neurosecretion of the hypothalamic area resulted in hyperactivity after the surgical stress. It was showed that gomoriphil substance and content of oxytocin and vasopressin in the anterior hypothalamus and neurohypophyse. decreased remarkably immediately after the stress. Administration of oxytocin proved to the increase of gonadotrophin secretion from adenohypophysis and increase of the secretion of gonadal androgens followed to.
Acetylcholin seemed to act as the transmitor in the central nervous system and to stimulate the neurosectetory function of the hypothalamus, resulting in the increase of pituitary-gonadal function in the same manner as the injection of oxytocin.
(3) With the use of potentialized anesthesia, hyperfunction of the neurosecretory system in the anterior hypothalamus was suppressed even after the surgical stress. Excretion of pituitary gonadotrophin, urinary 17-ketosteroids and its gonadal fractions did not increase according to the potentialized anesthesia. Administration of oxytocin or acetylcholin made the gonadotrophin-gonadal system accelerate even under the potentialized anesthesia.
It was concluded that the potentialized anesthesia might depress the release of acetylcholin and suppress the secretion of oxytocin and pituitary-gonadal function.
