Abstract
Since olden times numerous observations have been made upon the subject of the influence of the endocrine system upon the blood and blood-forming organs. In recent years, attention has been focused on this and related fields. However, most of these investigations studied the relationship between individual organs or their hormones and blood and not from the viewpoint of the general dyshormonism or dyssteroid-hormonism involved. Therefore, the author has tried to clarify the mechanism and the extent of the control exerted upon the blood and blood-forming organs (bone marrow, lymphoid and spleen) under the idea of dyssteroid-hormonism.
Chapter I.
75 matured hybrid rats were divided into normal and hypophysectomized groups and each group was again divided into several groups, i.e. the gonadectomized group and the groups administered estradiol, hexestrol, new synthetic estrogens of triphenyl-ethylene pattern-α-(β-methoxyphenyl)-β-β-diphenyl acrylonitrile (acrylo. der.), testosterone, methyltestosterone, MAD, cortisone, DOCA and progesterone daily for 1 month. The results are as follows.
1) The cellular elements of the blood and blood forming organs changed remarkably under several kinds of dyssteroid-hormonism and showed considerable differences between the sexes.
2) The testoid enhanced and the tolliculoid inhibited the homeostatic function of the animals for the red blood cell count, and the luteoid and the mineral corticoid were similar in action to the former. This tendency was recognized in the hypophysectomized animals of the lower grades. Only MAD stimulated the red cell formation, independent of the pituitary.
3) In the hyper-glucocorticoid milieu the anemia, the hypoplasia of the bone marrow and the increase of the fatty tissue in it were recognized.
4) The hypoplasia of the bone marrow, particulary a maturation arrest of the granulocytic cells were seen in the hypophysectomized animals and MAD considerably modified this inhibition, but any of the steroid hormones alone could not prevent this hypoplasia of the bone marrow.
5) In the non-pituitary milieu the lymph nodes and the spleen were, as a whole, atrophied, but only the pale centers were hyperplastic, with many mitotic figures. In the hyper- or hypo-sexual hormone milieu, the hyperplasia of the pale centers of the lymphoid tissue were seen and it was more intensified by the synthetic estrogen than by the natural estrogens of the same estrogenic activity. The acrylo. der. made the most hyperplastic lymphoid tissue like the giant follicullar lymphoma and this tendency was seen moderately after hypophysectomy. The luteoid and the mineral corticoid slightly inhibited the hyperplasia of the lymphoid tissue and cortisone induced a most severe atrophy of the lymphoid tissue.
6) In the dys-steroid hormone milieu the lymphoid tissue appeared as the proliferation of young Lymphocytic cells in the lymph node and there was hyperplasia of the reticulum cells in the spleen.
Chapter II.
Several new synthetic substances of the triphenylethylene derivatives were administered to 15 rats daily for a month. The results are as follows.
1) There is an inducing anemia factor and a factor causing an inhibition of the body weight increase in the triphenylethylene derivatives and their degree seems to parallel their estrogenic activities.
2) The lymphoid tissue proliferating activities of the triphenylethylene derivatives seems to be based upon their unique chemical structure and their intensity is considered to depend upon their estrogenic activities.
3) The cervical lymph nodes showed a stronger proliferation than the axillary, mesenterial, or retroperitoneal lymph nodes by estrogen administration.
Chapter III.
Follow up observations were made on the animals administered MAD, DOCA, cortisone and acrylonitrile der. And the same was done with the gonadectomized or adrenalectomized animals.
