Experimental Studies on the Direct Actions of Sex Steroids on Ovarian Functions (The First Report)

Abstract

The direct actions of some sex steroids on ovarian functions were studied using the longterm administration of those steroids to female albino rats, and the ovarian cholesterol and ascorbic acid contents before and after the combined administration of some gonadotropins (PMS and HCG) were determined.
Form the experimental data of mature female rat with regular sexual cycles, I found that the long-term sadminitration of estrogen or progesterone inhibited the sexual cycle not only through the hypothalamico-pituitary system but also through the direct action of these steroids to the ovary itself.
I obtained the same data with the experiment using immature female albino rat without sexual cycles.
From these experimental data it was concluded that the ovarian sex steroids have some direct regulatory or inhibitory action on the ovary itself, especially on its steroidogenesis.