Clinical Application of New Synthetic Corticotropin, DW-75 (D-Ser1-Nle4-Val25-β1-25-Corticotropin)
1970 Volume 46 Issue 5 Pages 534-538,503
Details
1970 Volume 46 Issue 5 Pages 534-538,503
A new synthetic corticotropin, DW-75 (D-Ser1-Nle4-Val25-β1-25-Corticotropin), was applied in normal subjects for adrenocortical function test. 25 IU or 0.04 mg of DW-75 was administered by (1) 6 hr. I.V. infusion, (2) single I.V. injection, and (3) I.M. injection. Plasma cortisol was determined fluorimetrically in these subjects before and successively after the administration of the synthetic corticotropin.
Urinary 17 OHCS and 17 KS were also studied. It was demonstrated that adrenal response was obtained maximally by the 6-hour-infusion method when observed by plasma corticsol level as well as urinary 17 OHCS exretion. In cases which received the single I.V. and I.M. injection, adrenal responses were less remarkable but plasma cortisol responded sufficiently enough to be used as a rapid stimulation test routinely.
No side effects were observed throughout the study in any of the subjects. It is suggested that the preparation can be used also for treatment purposes.
