Electrophoretic Analysis of Thyroid Hormone Binding Proteins in Human Sera

Abstract

It is a well-known fact that thyroxine (T₄) and 3, 5, 3′-triiodothyronine (T₃) are bound to special serum proteins in the blood, called T₄-binding proteins and T₃-binding proteins. It seems generally accepted that there are at least three kinds of T₄-binding proteins, which are T₄-binding prealbumin (TBPA), T₄-binding globulin (TBG) and albumin.
Recently, several investigators, however, have suggested that T₄ may be bound to another protein. With regard to T₃-binding proteins only few works have been done. The present study was designed to demonstrate and identify these T₄-and T₃-binding proteins by utilizing various techniques.