Studies on the Regulatory Action of Estrogen and Progesterone for the DNA Synthesis in the Endometrium
1973 Volume 49 Issue 1 Pages 17-31,2
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1973 Volume 49 Issue 1 Pages 17-31,2
Attempts have been made to study the effects of a hormone controlling the proliferation and differentiation of the endometrial tissue on DNA synthesis by the target cells as well as the working mechanism, the results are as follows :
1. Estrogen initiates the synthesis of DNA by the epithelial cells of the endometrium as early as at the outset of its action, bringing about a rise in the activity of thymidine kinase in approximately 18 hours and the eventual synthesis of DNA after 24 hours. The reaction of the interstitial cells, however, lacks uniformity as compared with the epithelial cells.
2. When the synthesis of protein in the uterine tissue was inhibited, most of the epithelial cells shifted to the synthetic stage of DNA. This result has led us to believe that the function of certain specific proteins are in the shift from GI-stage to S-stage. It is believed that the half-life of this protein is about 16 hours.
3. Progesterone has been proved to possess a potent effect inhibiting the synthesis of DNA. This inhibitory effect is produced through the conjugate action with said specific protein, and adrenaline has been proved to be involved in the working mechanism.
