Statistic Analysis for the Association of Hormone Dynamics and Biochemical Parameters with Bone Turnover in Surgically Induced Menopause
1993 Volume 69 Issue 11 Pages 1153-1168
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1993 Volume 69 Issue 11 Pages 1153-1168
The association between hormone dynamics and bone turnover was statistically examined in 52 women with surgically induced menopause. The mean values of 19 laboratory items which included hormones as well as parameters of bone metabolism were obtained and analyzed by Spearman's rank test. Linear regression models were established. Based on Pearson's correlation matrices, the principal components were analyzed. Metrics were formed from factor loading derived from Varimax's rotation, and their statistical significance was evaluated.
1. Significant correlations were determined from both the examination of the data analyzed separately at the levels of artificial menopause (bilateral and unilateral) and oophorectomy (OVX) method (bilateral or unilateral). For the patients who had bilateral OVX, the pairs showing a positive correlation (0.01<P, 0.05<P) were 1-25-(OH)2D with E2 or ASD, 25-(OH)D with E2, E3, Progesterone, or ASD, CT with Progesterone, ASD, or Testosterone, S.Al-P with FSH or LH, and S. Ca with LH. The pairs showing a weaker positive correlation were PTH with E2 or E3, CT with E2, E3 with S. Acid-P or U. Ca/CRN, and S. Ca with FSH. The pairs showing a negative correlation (0.01<P, 0.05<P) were S. Al-P with E2 or Progesterone, and S. Ca with Testosterone. The pairs showing a weaker negative correlation were S. Al-P with ASD. For the patients who had unilateral OVX, the pairs showing a positive correlation were 1-25-(OH)2D with E2, ASD, or Testosterone, 25-(OH)D with E2, E3, Progesterone, or ASD, CT with Progesterone, ASD, or Testosterone, and PTH with ASD. The pairs showing a weaker positive correlation were PTH with E2 or E3, and CT with E2. The pairs showing a negative correlation were S. Ca with Testosterone. The pairs showing a weaker negative correlation were S. Al-P with ASD. There was a small but significant difference between the two groups. However, Estrogen and Androgen in sex steroids, and S. Al-P, S. Ca, CT, PTH, 1-25-(OH)2D, and 25-(OH)D in bone parameters, all changed early or late at different rates but participated concomitantly with the high bone turn-over induced by OVX, particularly in bilateral.
2. Significant correlations among all parameters were determined for data analyzed at the level of artificial menopause. For the patients who had OVX, the pairs showing a positive correlation were E2 with 1-25-(OH)2D or 25-(OH)D, E3 with 25-(OH)D, Progesterone with 25-(OH)D or CT, ASD with 1-25-(OH)2D, 25-(OH)D, CT, or PTH, Testosterone with 1-25-(OH)2D, 25-(OH)D, or CT, FSH with S. Al-P, LH with S. Al-P or S. Ca, S. Al-P with S. Ca, S. P, or S. Acid-P, S. Ca with S. P or S. Acid-P, 25-(OH)D with 1-25-(OH)2D or CT, U. Ca with U. P, and U. P/CRN with CT, U. Ca/CRN, or U. P. The pairs showing a negative correlation were S. Al-P with E2 or Progesterone, Testosterone with S. Ca, ASD with FSH or LH, and CT with S. Ca or U. P. Through analysis of the principal components and Varimax's rotation after OVX, the indices were divided into pertinent groups, and their relationship was determined. FSH and LH formed one group which demonstrated an isodirectional relationship with S. Ca and S. P with S. Al-P acting as an intermediary. By contrast, this group showed a reverse directional relationship with E2, 25-(OH)D, CT and Testosterone formed another group which had an isodirectional relationship with ASD and showed a reverse directional relationship with U. P, E2, ASD, and 1-25-(OH)2D made up another group. U. P/CRN, U. P, and S. Acid-P formed another group. U. Ca/CRN and U. Ca formed another group.
