Abstract
Breeding experiment was designed to obtain diabetic strains of mice for medical researchs.
Several strains of mice were examined for diabetes, and KSB was newly found to be diabetic with consistent glycosuria in females and decreased ability of assimilation of glucse in both sexes. Such diabetic tendencies were widely observed among other strains, NC, NB, NBC and DDK. Diabetic characteristics of KK and AY were reconfirmed.
Interoduction of the Ay gene into KK by successive backcrosses was effective to breed a serious diabetic strain, KK-CA, with severe glycosuria, hyperglycemia and abnormal glucose tolerance curve. This strain will be useful as an experimental tool in the study of diabetes mellitus. The other program of the selection of severe diabetic mice from the F2 progenies between two diabetic strains, KK and KSB, was also successful to obtain diabetic mice in the F3, with significant effect of selection, but the breeding program was discontinued because of low fertility in successive generations.
