Abstract
Studies were made on the blood picture of mice following intraperitoneal injection of pertussis toxin and-vaccine.
Female mice of 4 weeks' old, CF#1 (HIKARI) were used in this experiment.
Pertussis-toxin caused marked leucocytosis on the 1st day, which gradually recovered and the normal picture was resumed in 15 days. Pertussis-vaccine also developed leucocytosis, which was most eminent on the 3rd to 6th day. The leucocytosis caused by toxin as well as vaccine was principally that of neutrophiles. The toxin caused slight erythrocytosis on the 1st day, and moderate anemia on the 9th day. No essential difference between the toxin and the vaccine was demonstrated.