EXPERIMENTAL ANIMALS
Online ISSN : 1884-4170
Print ISSN : 0007-5124
ISSN-L : 0007-5124
Relationship between Sensitivity of Mice to Bacterial Infection or Drugs and Their Leucocytes Pictures (A comment on the opinion of TABEYI)
NOBUO KATO
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JOURNAL FREE ACCESS

1958 Volume 7 Issue 6 Pages 181-187

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Abstract
To examine the reproducibility of the works of TABEYI et al., sensitivity of male ddN mice to the infection withSal. euteriticlisand to the injection with acetylcholine was tested. Mice were divided into two groups after examination of their blood pictures. The one group contained mice of which leucocytes pictures showed one of TABEYI's indexes for sensitivity; namely myelocyte, metamyelocyte, more than 3.5 per cent eosinophilic leucocyte, more than 10 per cent monocyte and plasma cell. The other was those which did not show the indexes. LD50of acetylcholine inject-ed intravenously was 17.4mg per kg body weight in the former group and 13.5mg in the latter. When 10-4mg ofSal. enteritidisS64 were inoculated intraperitoneally, mortality was 8/10 (periods of death 6-12 days) in the former group and 9/10 (periods off death 6-9 days) in the latter. The results did not agree with the opinion of TABEYI. Based on the results it was stated that his opinion might have errorneous points.
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© Japanese Association for Laboratory Animal Science
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