Examination of Potency Test of an Adsorped Freeze-dried Swine Erysiperas Vaccine.Especially on the Importance of Mouse-selection in the Experiment

Abstract

At its 10 Session, the Expert committee on Biological Standardization of WHO asked the Central Veterinary Laboratory, Weybridge, in collaborative with Paul Ehrlich Institute, Frankfurt, to arrange a collaboration examination of an adsorped freeze-dried swine erysiperas vaccine for its stability and performance in assay with a view to its use as the International Standard. It was noted at the 11th Session that preliminary collaborative examination by the two laboratories mentioned above had shown the suitability of such a preparation and the Paul Ehrlich Institute was asked available a large quantity of a similar material. The samples were distributed to our laboratory, so we performed the comparative assay test on the materials.
As shown in Chart, mice of dd strain showed a parallelism in two trials and a definite relation between vaccine doses and servival rates, while non-selected mice showed a very great discrepancy in the points of above-mentioned facts.
The detail is to be reported by Ando et al. in the near future.