Abstract
Female germfree (Gf) and conventional (Cv) ICR mice aged 21-25 days were administered with hCG (50IU/head/day for 2 days) . Six hours after the last administration, uterine weights of Gf and Cv mice were 175.8 mg % and 238.7 mg % respectively, the difference between Gf and Cv animals was statistically significant (p<0.05) . Ovariectomized Gf and Cv mice aged 80-150 days were successively administered with estradiol benzoate (0.02 mg/head/day for 5 days) . Six hours after the last administration, uterine weights of Gf and Cv mice were 358.8 mg % and 462.7 mg % respectively, being statistically significant between Gf and Cv animals (p<0.01) . After administration of estradiol benzoate (0.02 mg/head/day for 2 days), 1.0 mg/head/day of progesterone for 3 days were given ovariectomized Gf and Cv mice aged 80-150 days. Six hours after the last administration, uterus of Gf and Cv mice were weighed 337.6 mg % and 423.5 mg % respectively, the difference was statistically significant (p<0.01) . Castrated Gf and Cv mice aged 80-150 days were administered with 1.0 mg of testosterone propionate (head/day for 5 days) . Six hours after the last administration, weights of seminal vesicle and coagulating gland of Gf and Cv mice were 376.0 mg % and 611.8 mg % respectively, the difference was statistically significant (p<0.01) .
