Body Weight Changes of Mice with Different Immunity to Sendai Virus after Challenge Infection

Abstract

Four groups of mice immunized with Sendai virus in different ways, namely convalescent (CT), intrapertoneally (IP) or intranasally (IN) immunized with the inactivated virus and non-immunized (NOI), were challenged and examined degree of immunity and body weight changes. Degree of immunity assessed based on the antibodies, the lung lesions and the lung viral titers was higher in order of CT, IP, IN and NOT. Body weight changes, expressed by both the decrease in mean body weights and the oorrelation corefficients between pre-and post-challenge, were less in the mice with higer immunity against Sendai virus.