Elevated Free Cholesterol Content in Hindleg Muscle of the Dystrophic Mouse during a Postnatal Period from 2.1 to 30 Weeks

Abstract

Age-related changes in phospholipid and free cholesterol contents of hindleg muscles fromnormal and dystrophic (C57BL/6Jdy/dy) mice were investigated. Free cholesterol contents in liver, whole blood and brain of dystrophic mice at 3 weeks of age were also compared with the control. Free cholesterol content tended to increase in the liver of the dystrophic mouse. Free cholesterol content of dystrophic muscle was significantly higher than that of normal muscle at each age (2.1 to 30 weeks old), while phospholipid contents in dystrophic muscles were nearly equal to those of the normal in age from 4 to 20 weeks.