Strain Differences in Histamine Release from Mouse Peritoneal Mast Cells Induced by Compound 48/80 or A₂₃₁₈₇

Abstract

Strain differences among BALB/c, BDF₁, CDF₁, C3H/He, C57BL/6, DBA/2, ddy and ICR mice were investigated with respect to the ratios of histamine release from mouse peritoneal mast cells induced by compound 48/80, a Ca²⁺ dependent histamine releaser, and the Ca²⁺ ionophore A₂₃₁₈₇. The ratios of histamine release from mouse peritoneal mast cells induced by compound 48/80 were found to be high in BALB/c, ddY and ICR mice, but low in BDF₁, CDF₁, C3H/He, C57BL/6 and DBA/2 mice. Those induced by Ca²⁺ ionophore A₂₃₁₈₇ were high in BALB/c, BDF₁, CDF₁, C3H/He, DBA₂, ddy and ICR mice but low in C57 BL/6 mice. These results indicate that differences in histamine release from mouse peritoneal mast cells are strain dependent.