1989 Volume 38 Issue 4 Pages 349-352
ICGN is a strain of spontaneous nephrotic mice with nonproliferative glomerular lesions. It was derived from an outbred Yok : ICR colony in our laboratory. The renal disease constantly occurred in animals of the first to the tenth generations (>13.0%; 70 days of age) . When affected males were mated with unaffected females, the incidence of the disease in their offspring was 38.8% (n=49) at 70 days after birth. When both parents were affected, their offspring were all affected (n=12) . The disease evenly progressed in both sexes. It usually began 40 to 150 days after birth and death occurred within two months after onset. The animals usually showed sufficient reproductive ability as long as unaffected females were used for mating.
Proceedings of The Japanese Society of Animal Models for Human Diseases
Proceedings of The Japanese Association of Animal Models for Human Diseases
