Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 0007-5124
Kidney Complications in EMC Virus-induced Diabetes in Conventional DBA/2 Male Mice
Kazuhiro SHICHINOHEMasumi SHIMIZUMasamichi ISHIZAKIMitsuo ASAKAWA
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1990 Volume 39 Issue 1 Pages 113-116

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Abstract

Conventional DBA/2 male mice of about 9 weeks of age were inoculated by intraperitoneally injecting EMC virus M variant (104TCID50/0.1 ml/animal) which is passaged in mice. The mice which tested positive for glycosuria and hyperglycemia were examined histopathologically 2 or 5 months after inoculation. The kidneys were examined for thickening of Bowman's capsule and the mesangial matrix. These changes were more clearly observable 5 months after inoculation than they were 2 months after inoculation.

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© Japanese Association for Laboratory Animal Science
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