Antinucleolar Autoantibody Induced in Mice by Mercuric Chloride

—Strain Difference in Susceptibility—

Abstract

Eight inbred mouse strains were examined for their reactivity to the induction of antinucleolar autoantibody (AnuA) by mercuric chloride (MC) . According to the positive ratio and titer of AnuA induced, the strains were grouped into high-, moderate-, low-, and non-responders. Since the susceptibilities to MC were different among strains having the same H-2 haplotype, involvement of H-2 unlinked gene (s) in AnuA induction by MC was suggested.