Establishment of a Congenic Strain with Complement Regulatory Protein of Factor H Allotype Derived from Mus. musculus molossinus

Abstract

Factor H is a plasma glycoprotein with M. W of 160 KDa which serves as one of the regulatory proteins for C3 convertases. We have previously reported three serologically defined mouse factor H allotypes by surveying many laboratory and wild mice. In the present work, we established a congenic strain with factor H allotype, H. 2, on BALB/c (H.1 allotype) background and named this strain BALB-H. 2. Alloantiserum against each allotype has been easily prepared using two congenic strains by immunization with a small amount of whole mouse serum. BALB-H. 2 is valuable for the genetic studies on the genes in the vicinity of factor H gene (cfh) derived from Mus. m. molossinus.