Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 0007-5124
Experimental Pulmonary Metastasis of Chinese Hamster Mesenchymal Chondrosarcoma Cell Lines
Nobuyoshi FUJISAWANorimitsu L. SATOTeiichi MOTOYAMA
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1994 Volume 43 Issue 5 Pages 761-764


Pulmonary metastases of chinese hamster mesenchymal chondrosarcoma cell lines, MCS-1 (undifferentiated type) and MCS-8 (differentiated type), were examined by intravenous transplantation into athymic nude mice.
The incidence of pulmonary metastasis of MCS-1 was 100% and that of MCS-8 was 33% at the 23rd day after transfer. Mean number of metastatic nodules in the lung was 41 in the former and only 3 in the latter. Mean survival time of mice with MCS-1 injection (5×104 cells) was 27 days and that with MCS-8 (5×104 cells) was 48 days after transfer. At the 42nd day after transfer of MCS-8, however, the incidence of pulmonary metastasis was 100%. These data suggest that the tumor growth rate in the metastatic lesion, as well as the affinity to the target organ, is very important for evaluation of experimental metastasis.

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© Japanese Association for Laboratory Animal Science
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