Experimental Pulmonary Metastasis of Chinese Hamster Mesenchymal Chondrosarcoma Cell Lines
1994 Volume 43 Issue 5 Pages 761-764
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1994 Volume 43 Issue 5 Pages 761-764
Pulmonary metastases of chinese hamster mesenchymal chondrosarcoma cell lines, MCS-1 (undifferentiated type) and MCS-8 (differentiated type), were examined by intravenous transplantation into athymic nude mice.
The incidence of pulmonary metastasis of MCS-1 was 100% and that of MCS-8 was 33% at the 23rd day after transfer. Mean number of metastatic nodules in the lung was 41 in the former and only 3 in the latter. Mean survival time of mice with MCS-1 injection (5×104 cells) was 27 days and that with MCS-8 (5×104 cells) was 48 days after transfer. At the 42nd day after transfer of MCS-8, however, the incidence of pulmonary metastasis was 100%. These data suggest that the tumor growth rate in the metastatic lesion, as well as the affinity to the target organ, is very important for evaluation of experimental metastasis.
Proceedings of The Japanese Society of Animal Models for Human Diseases
Proceedings of The Japanese Association of Animal Models for Human Diseases
