Abstract
It is well known that cholesterol ester accumulate in atherosclerotic arterial wall. In this paper, two monoclonal antibodies against lipid laden cells (FCR1a/201F) and extracellular matrix where lipid deposited (EMRIa/212D) are discussed.
FCRIa/201F recognized lipid laden cells from both Watanabe-Heritable Hyperlipidemic rabbit and human atherosclerotic aorta. The cells probably both macrophages and modified smooth muscle cells are transformed to lipid laden cells during accumulation of cholesterol ester. EMRIa/212D recognized extracellular matrix where lipid deposited. Antigenic substances against this antibody must be glycoprotein, the epitope of which is sialic acid.
These evidences obtained from experimental atherosclerotis (WHHL rabbit) may help understanding how lipid accumulate in arterial wall in human patient.
