2022 Volume 72 Issue 1 Pages 37-42
Abstract:Mucinous borderline ovarian tumors （MBOT） are known to have a good prognosis with a low recurrence rate, and most recurrences occur in the abdominal cavity. We herein describe a case of MBOT which recurred with metastasis to the lung one year following initial surgery. A 60-year-old female gravida 2 para 2 presented to her local clinic complaining of exertional dyspnea lasting over one cytokeramonth. She was found to have a pelvic tumor and pleural effusions, and was referred to the department of obstetrics and gynecology of Fukushima Medical University Hospital for further examination. A multilocular cystic tumor measuring 15 cm in diameter was observed via imaging, leading to a suspicion of ovarian cancer, and abdominal, simple hysterectomy, bilateral adnexectomy, and partial omentectomy were performed. The tumor was histologically diagnosed as pT1cN0M0 stage IC MBOT. The patient was followed up without any adjuvant chemotherapy ; however, a CT taken 1 year following surgery revealed nodular shadows, with one each in both lower lung fields. A thoracoscopic bilateral lung lobectomy was conducted, and the resected lung lesion indicated morphological similarities to the ovarian tumor （MBOT）. Furthermore, because the immunohistological profile of the lung lesion and the ovarian tumor matched, and thyroid transcription factor-1（TTF-1）, which is usually positive in primary pulmonary adenocarcinomas, was negative. Based on these findings, we diagnosed the lung lesion as a metastatic recurrence of MBOT. Although lung metastatic recurrence of MBOT is very rare, there are reports on recurrence in the early stages or after a long interval following initial surgery, thus suggesting a need for long-term surveillance of tumor recurrence including the lungs metastasis, regardless of the disease stage.
