Folia Pharmacologica Japonica
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
Review
Heat shock protein 27 in osteoblasts
Osamu KOZAWAHaruhiko TOKUDA
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Keywords: HSP, osteoblast, MAP kinase, PKC
JOURNAL FREE ACCESS

2002 Volume 119 Issue 2 Pages 89-94

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Abstract
Physiological stresses such as heat stress, chemical stress and mechanical stress induce the expression of heat shock protein (HSP) families in cells, which affects cell function. In the present review, we describe HSP27, a small HSP in osteoblasts, especially the regulatory mechanism of the induction of HSP27 stimulated by physiological bone agents. Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the arachidonic acid cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC). On the contrary, physiological regulators of bone such as endothelin-1, prostaglandin F (PGF), PGD2, and basic fibroblast growth factor (bFGF) induce HSP27 via protein kinase C (PKC) activation. In addition, the mitogen-activated protein (MAP) kinase superfamily takes part in the HSP27 induction. Thus, not only stress but also physiological agonists induce HSP27 in osteoblasts, and PKC or MAP kinases play important roles in the induction of HSP27.
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© 2002 by The Japanese Pharmacological Society
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