New trends on alternative to animal testings in Japan

Abstract

Non-animal alternative test methods have developed in the field of genotoxicity, endocrine disrupter, irritation and skin sensitization, and these are used the safety evaluation of chemical, pesticide, pharmaceutical and cosmetic for regulatory use. For the systemic toxicological endpoints of repeated dose toxicity, carcinogenicity, immunotoxicity and reproductive toxicity, new test methods are expected to be developed in the future worldwide. I believe Japan will make a significant contribution to these developments.