Roles of endogenous hydrogen sulfide in the bladder and prostate

Abstract

Recently, hydrogen sulfide (H₂S) has been recognized as the third gasotransmitter besides nitric oxide and carbon monoxide, and it has been reported that H₂S exhibits various physiological functions such as neuromodulation and vasorelaxation. In the lower urinary tract (bladder and prostate), it is reported that donors of H₂S induce contraction of the rat detrusor and relaxation of the pig bladder neck. These reports suggest a possibility that H₂S may have site-specific effects on the bladder. However, the detailed functions of H₂S in each part of the bladder are still unclear. In addition, there is no report showing physiological roles of H₂S in the prostate. In this article, we will review the distribution of enzymes related to H₂S biosynthesis and physiological roles of H₂S in the lower urinary tract based on reports from our and other groups. We will also introduce a possibility that H₂S can be a new therapeutic target against lower urinary tract symptoms (LUTS) based on our data from spontaneously hypertensive rats (SHRs), which develop hypertension-mediated LUTS.