Abstract
Ringer-Locke's solution had been continuously infused with a uniform velocity, i. e. about 5, 10 or 20 c.c. per kilogram per minute, under the skin of rabbits, poisoned with chloral hydrate or rendered anaemic by a profuse bleeding, until they died. The following are the results thus obtained :
The total amounts of Ringer-Locke's solution causing the death of animals decrease by chloralization, and slightly increase by a profuse bleeding. But in both cases the renal excretion during the infusion is markedly reduced. Hardly any influence of the infusion can be seen on the blood pressure which has been intensely reduced by chloral hydrate, whereas the low pressure due to a previous bleeding rises gradually, when the infusion is going on. Although in the slowest infusion this pressoric effect is very marked, yet animals succumb at last under dyspnoea before the blood pressure reaches its normal height again. Excepting agonal dyspnoea, the influence of the infusion on the respiration is not always noteworthy. Autoptical findings in both cases are like to those in the normal animal. Gelatinous swellings of the subcutaneous tissues, a conspicuous anasarca, a considerable stagnation with haemorrhages in the lungs, etc. are the most striking facts.
