Effects of NIK-247 on the spontaneous EEG of normal and nucleus basalis magnocellularis lesioned rats.

Abstract

Effects of oral administration of NIK-247 (9-amino-2, 3, 5, 6, 7, 8-hexahydro-1H-cyclopenta-[b]quinoline monohydrochloride monohydrate) and THA (9-amino-1, 2, 3, 4-tetrahydroacridine hydrochloride hydrate) on the EEG of normal and nucleus basalis magnocellularis (NBM) lesioned rats were examined. NIK-247 at 1mg /kg and 3 mg/kg did not show any effects on the EEG of normal rats, but NIK-247 at 10 mg/kg significantly lowered the total power of the cortical EEG in normal rats. THA at 3 mg/kg and 10 mg/kg also decreased the total power of cortical EEG in normal rats. In the NBM-lesioned rats, decreases of delta wave activity as well as the total power of cortical EEG were observed with both NIK-247 and THA at 3 mg/kg, respectively. The arousal effects of these two drugs were comparable to the effect of physostigmine, suggesting the central cholinergic effects of both NIK-247 and THA.