Spinorphin is an endogenous pain-regulated subustance which modulated an enkephalin-degrading activity. Recently, we found that Spinorphin inhibited 02-generation, exocytosis of β-glucuronidase and collagenase by human neutrophils(PMNs) stimulated with FMLP as an inflammatory mediator. In this study, we examined whether Spinorphin exerts anti-inflammatory effects on λ-Carrageenan-nduced acute inflammation in the mouse air pouch.
