Abstract
1. Mice were used to record the spinal reflex potentials and to examine the effects of some drugs upon them. In anesthetized mice, mono- and polysynaptic reflex (MSR and PSR) potentials were recorded. TRH and DOI produced transient and long-lasting increases in the MSR amplitude, respectively. Tolperisone and baclofen produced transient and long-lasting MSR depression, respectively. These results show that similar data can be obtained from mice and rats. 2. Cytosine arabinoside induced-ataxic mice (Ara-C mice) were employed as an animal model of spinocerebellar degeneration. Taltirelin, a remedy for spinocerebellar degeneration, augmented the MSR in Ara-C mice. Effects of prazosin and mazindol on the MSR suggested that the function of descending noradrenergic systems was depressed in Ara-C mice.
