Abstract
The mode of action of glycols as vehicle and solvent to the penetration. of antibacterial activity of furan derivatives was previously investigated (See no. 8 and 11 of this Breviaria). in this study we observed influences of surface active agents [Tween 80, Span 80, Emasol 110, Aerosol 1B] in vehicles (carbowax (PEG, ) petrolatum, Unguentum simplex) and solvents [water, propylene glycol (PG, ) olive oil] on the antibacterial penetration of furacin. The paper disc agar plate method known in quantitative analysis of penicillin and the one dimensional diffusion method widely used as a biological method for assaying antibiotics were used as in the previous experiment. Staphylococcus aureus Terashima was used as a test strain. The results obtained were as follows : (1) The penetration of furacin in PEG-base was not influenced or slightly by the concentration of 10% each agent contained in the base. (2) The penetration of furacin in petrolatum and Ung. simplex was increased a little by Tween 80, Span 80 and Emasol 110 though it was not by Aerosol 1B. (3) Furacin in water, 30%FG-water solution and F G penetrated more markedly in the presence of Aerosol 1B than in the presence of Tween 80, Span 80 or Emasol 110. (4) When olive oil was used as a solvent, the penetration of furacin was decreased by Tween 80, Span 80 and Emasol 110 but it was not affected by Aerosol 1B.
