Abstract
Quantitative estimations of free santonin were determined in-the urine and intestinal tract of a rabbit following oral, subcutaneous and intravenous administration. The analytic method for this purpose was previously reported in detail (Nagasaki Igakkai Zassi in press).. The results obtained were as follows : (1) The ratio of the quantity of santonin excreted in the urine to the dose amounted to 6.7 27.7 % after oral administration ; to 64.9 77.4%; after subcutaneous administration of sodium santonin ; to 673-82.8 % after intravenous administration of the salt. Since individual variations in the excretion of santonin are great, the same rabbit was used to avoid experimental error. (2) Most of the santonin was excreted within the first 9 hrs. after oral administration, and in the first 3 hrs. after injection of sodiums santoninate. (3) Whenever oral administration of santonin was repeated in a rabbit excreting a large quantity of the drug at the first administration, the amount excreted in the urine, fell to a constant value after several administrations. (4) No santonin could be detected in the feces, but a qualitative test for santonin was positive in the bile and intestinal tract. (5), Seven rug of santonin (1%) was found in the bile of a rabbit whose liver and kidneys were injured by repeated large doses of santonin.
