Abstract
In a series of chemical and chemotherapeutical researches on the nitrofurylacrylic acid derivatives it was proved that 5-nitro-furyl-acrylylaminoethanol (NFA) had a strong antibacterial activity against Grampositive as well as -negative bacteria. Result: NFA inhibits the growth of Shigella dysenteriae and Eberthella typhosa in a highly diluted concontration as much as 1:256000, while with 1:128000 of furacin Shigella dysenteriae are suppressed. NFA is a slightly yellowish crystal, which is melt at 151 ?? 152°C and dissolved in water to the dilution of 1:20 when boiled and to 1: 160 at 50%deg;C. At a very low temperature NFA is dissolved to 1:500, while furacin to 1: 5000. The penetrating capacity of NFA into an agar-medium is about 50 times as strong as that of furacin. MLD per 20 g body weight of mice is 20 mg by NFA and 5 mg by furacin respectively when applied orally.
