Abstract
4-α-Dimethylaminopropionylaminoantipyrine (No. 7) showed a far stronger analgesic action and a far weaker toxicity than aminopyrine (A), but no antipyretic action (J. Pharm. Soc. Jap. 73, 437, 1953). In the case of a combined use of both drugs the analgesic action was synergistically increased and the antipyretic action of A in febrile rabbits was elevated. No. 7 raised also the solubility of A and reduced its toxicity. Further, the influence of adrenolytics as priscoline and cholinergics as prostigmine on the analgesic action of No. 7 and A was investigated.
